Genome Structure, Stability, and Evolution
Exploring the complex and dynamic landscape of the eukaryotic genome
Our Research Interests
How does the structure of a genome evolve over time? Our research investigates the molecular causes and phenotypic consequences of the broadly defined family of genomic features known as structural variations (SVs). SVs like aneuploidy, loss-of-heterozygosity, and copy number alteration are pervasive, yet poorly understood genomic elements which contribute significantly to the genotypic and phenotypic diversity of eukaryotic populations. Our current work is addressing many fascinating and important biological questions focused on understanding how SVs arise in the genome, and how these variations contribute to genome stability and evolution, phenotypic diversity, and cellular and organismal fitness.
Our doors opened in the Dept. of Biochemistry and Molecular Genetics at the University of Colorado Anschutz Medical Campus in August 2022!