How does the structure of a genome evolve?
How do SVs shape the architectures and life histories of populations and species?
The concerted efforts of yeast geneticists to collect and characterize >1000 natural isolates of S. cerevisiae have made it a robust model system with which to study organismal evolution. Using Oxford Nanopore single molecule long read WGS to characterize the genomic structures of these wild isolates, we have initiated a systematic investigation of the structural genomic architectures of wild strains of S. cerevisiae in order to answer the following questions: How much structural variation exists within a species and how does this impact the reproductive potential of that species? How do structural variations enforce reproductive barriers and isolation within and between related species? How does the life cycle of an organism impact the genomic architectures of distinct populations? How does structural genomic evolution modulate phenotypic variation and heterogeneity in populations of related individuals?